Neuroprotective Effects of Guanosine Supplementation in Experimental Models: A Systematic Review

Abstract

Cite this article: Bezerra APDC, Pedrosa ECGA, Costa IMD, Cavalcanti JRLDP, Oliveira LCD, Araújo DPD, Rego ACMD, Filho IA, Pinheiro FI, Guzen FP. Neuroprotective Effects of Guanosine Supplementation in Experimental Models: A Systematic Review. Pharmacog Rev. 2019;13(26):x-x. ABSTRACT Guanosine (GUO) is an endogenous guanine nucleoside to which several neuroprotective and neurotrophic effects have been attributed in experimental in vitro and/or in vivo models of central nervous system (CNS) diseases, including ischemic stroke, Alzheimer’s, Parkinson’s disease, spinal cord injury, nociception and depression. The objective of this work is to systematically review the neuroprotective effects of guanosine in experimental models in the CNS. The research was conducted through PubMed, Science direct, Scopus, Cochrane Library and SciELO (Scientific Electronic Library Online) and databases, where a number of relevant articles were found. Central nervous system (CNS) astrocytes release guanosine extracellularly, that has trophic effects. In the CNS, extracellular guanosine (GUO) stimulates mitosis, the synthesis of trophic factors and cell differentiation, including neuritogenesis, is neuroprotective and reduces apoptosis due to various stimuli. In this work we demonstrate that guanosine has a neuroprotective effect, through the survey of data that we carry out.