Intracranial Pleomorphic Malignant Fibrous Histiocytoma, Associated to Systemic Lupus Erythematous: A Case Report

Abstract

Background: Pleomorphic Malignant Fibrous histiocytoma (MFH) is a rare neoplasms of the soft tissue and bone composed of fibroblastic and histiocytic components with mitosis figures, nuclear pleomorphism and anaplasia. Case Presentation: We presented a rare case of MFH in 44 year old woman with history of systemic erythematosus lupus and seizures. Treated with prednisone. The cerebral TAC showed a temporal mass. Craniotomy was performed and the examination of the biopsy sample revealed a giant, pleomorphic and atypical cells. Immunohistochemical analysis showed positivity for vimentin, CD68, Fascin, lysosyme and MIB-1 labeling index of 20%. Pleomorphic malignant fibrous histiocytoma was diagnosed, with involvement of the overlying temporal lobe. We report a case of MFH of the left temporal in adult. Discussion: The neuroimaging and intra-operative opinion were of a meningioma. Histopathology, Case Study Tena-Suck et al.; BJMMR, 21(9): 1-8, 2017; Article no.BJMMR.32743 2 in conjunction with immunohistochemical evaluation and proliferation marker, confirmed the diagnosis. This is the firth case reported of PMFH associated to systemic lupus erythematous and different histological patterns.