Synthesis, Antioxidant and Toxicity Activity of Compounds (E)-1-(3-bromophenyl)-3-p tolylprop-2-en-1-on

Abstract

Halogen substituted analog compound chalcone (E)-1-(3-bromophenyl)-3-p-tolylprop-2-en-1-on was synthesized from 4-metylbenzaldehyde as aldehydes with 3bromoacetophenone, as ketones by using aldol condensation reaction. The compound resulted rendement with value of 62,38% and characterized by using UV, IR, MS, and 1HNMR. Test of antioxidant activity using DPPH method showed that those compounds have low potency as antioxidant agent LC50 with value 571, 7903 ppm. Toxicity tests using Brine Shrimp Lethality Test (BSLT) showed that those compounds have a potency as anticancer agent with LC50 value