Evaluation of the acute and subchronic toxicity of the aqueous extract of the leaves of Clerodendrum thomsoniae Linn in oral route

Abstract

Paracelsus (1493-1541) reported that all substances are poisons, only the right dose can distinguish a poison from a drug. Toxicity is the intrinsic ability of a chemical or physical agent to have a harmful effect on an organism. It is the capacity specific to various substances whose absorption of single or repeated doses has the effect of disturbing the metabolism of living beings, causing physiological disorders which can go as far as the death of exposed individuals (Ramade, 2002). According to Stéphane Malard (2018), the harmful effect is any alteration due to treatment deviating from normality taken as a reference, which reduces the ability of an organism to survive, reproduce or adapt to the environment.