3D bioprinting for vascular grafts and microvasculature

IF 6.8 3区医学 Q1 ENGINEERING, BIOMEDICAL

International Journal of Bioprinting Pub Date : 2023-08-02 DOI:10.36922/ijb.0012

Junpeng Zhu, Xinwang Wang, Lin Lin, W. Zeng

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引用次数: 1

Abstract

Cardiovascular disease is the world’s leading cause of death, and there is a substantial clinical need for transplantable blood vessels. Through tissue vascular engineering technology, large blood vessel grafts with significant clinical effects have been synthesized. However, synthesizing vascular valves, small vessels up to 6 mm in diameter, and capillary networks up to 500 μm in diameter remains challenging due to the lack of precise manufacturing techniques. In particular, constructing a microvascular network in thick tissue is the technical bottleneck of organ transplantation. Three-dimensional (3D) bioprinting is a computer-assisted layer-by-layer deposition method that can deposit cells and biomaterials at a predetermined location, according to an accurate digital 3D model, to build a delicate and complex bionic structure. This review discusses the progress and limitations of 3D bioprinting in preparing large vessels and valves, small-diameter vessels, and microvascular networks. This paper focuses on improved printing technology and innovative bio-ink materials. The future application of 3D bioprinting is prospected in generating artificial blood vessel grafts and vascularized organs with full biological function.

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用于血管移植和微血管系统的3D生物打印

心血管疾病是世界上导致死亡的主要原因，对可移植血管的临床需求很大。通过组织血管工程技术，合成了具有显著临床效果的大血管移植物。然而，由于缺乏精确的制造技术，合成血管阀、直径达6mm的小血管和直径达500 μm的毛细血管网络仍然具有挑战性。特别是在厚组织中构建微血管网络是器官移植的技术瓶颈。三维(3D)生物打印是一种计算机辅助的逐层沉积方法，可以根据精确的数字3D模型将细胞和生物材料沉积在预定位置，以构建精致复杂的仿生结构。本文综述了3D生物打印在制备大血管和瓣膜、小直径血管和微血管网络方面的进展和局限性。本文的重点是改进的印刷技术和创新的生物墨水材料。展望了生物3D打印技术在制造人工血管移植物和具有完整生物功能的血管化器官方面的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Bioprinting Multiple-

CiteScore

6.90

自引率

4.80%

发文量

期刊介绍： The International Journal of Bioprinting is a globally recognized publication that focuses on the advancements, scientific discoveries, and practical implementations of Bioprinting. Bioprinting, in simple terms, involves the utilization of 3D printing technology and materials that contain living cells or biological components to fabricate tissues or other biotechnological products. Our journal encompasses interdisciplinary research that spans across technology, science, and clinical applications within the expansive realm of Bioprinting.