Formulation process of a biopesticide based on the Erinnyis ello betabaculovirus ErelGV: unit operations analysis

Abstract

The use of bioproducts developed from active viral ingredients is a promising strategy in integrated pest management. Accordingly, the VG010 betabaculovirus has been identified as an effective agent in controlling the hornworm Erinnyis ello. The development of a wettable powder formulation using VG010 as an active ingredient in a biopesticide must have a guaranteed efficacy. An analysis of the unit operations involved in the formulation was carried out using proper operating conditions and production equipment. The active ingredient and finished product characterization revealed the repeatability of variables among batches. The mixing and drying processes were evaluated using operational parameters such as the mixing index and drying kinetics. From this analysis, the most favorable mixing time and drying temperature were selected to obtain a homogeneous product and high insecticidal activity. Viral concentrations, pH of the liquid mixtures, and drying temperature were established as control parameters of the critical points.