Risk Factors, Bleeding Disorder and COVID-19 in Bamako, Mali

Abstract

Introduction: Patients with COVID_19 infection have been shown to have an increased thrombotic risk, due to activation of coagulation secondary to sepsis. Objective: To study biological markers correlated with blood clotting disorders in hospitalized patients with COVID_19. Method: This was a retrospective descriptive and analytical cross-sectional study conducted at the Mali Hospital between September 2020 and January 2021. The markers being biologically monitored were: PT, ACT, INR, D-dimer and Troponin-I. Result: A total of 134 patients were enrolled in our study. Male was in the majority than female with 62.68% male and 37.31% female. The age group from 20 to 50 years was the most represented, at 58.21%. Biological markers showed plasma D-dimer concentration > 0.5 μL, PT ˂ 70, INR > 3; an ACT > 40 seconds and a Troponin > 0.1 μL for 76.11%, 10.44%, 15.67%, 16.41% and 1.49% of the study population respectively. The rate of cured patients was 94.02% and that of deceased patients was 5.97%, with all deceased patients having a high D-dimer level. Conclusion: Blood clotting disorders and elevated D-Dimer are important biomarkers predicting complications of COVID_19 infection.