RISK FACTORS OF HYPEREMESIS GRAVIDARUM: META-ANALYSIS FROM RETROSPECTIVE COHORT STUDIES

Malaysian Journal of Public Health Medicine Pub Date : 2022-12-21 DOI:10.37268/mjphm/vol.22/no.3/art.1678

Artha Budi Susila Duarsa, Aris Widiyanto, I. P. Dedy Arjita, Joko Tri Atmojo, Ayu Anulus, Santy Irene Putri, Asruria Sani Fajriah

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引用次数: 0

Abstract

Hyperemesis gravidarum (HG) is a pregnancy condition characterized by prolonged and severe nausea and vomiting of pregnancy, which causes dehydration and weight loss that requires extensive medical care and hospital admission. Studies of hyperemesis were limited in statistical power and generalizability as a result of being facility-based and relatively small in size. This study aimed to investigate the factors associated with HG among pregnant women. It systematically reviews articles published in PubMed, EMBASE, and Science Direct databases. Statistical analysis was carried out by Review Manager 5.3 (RevMan 5.3). Three hundreds and eighteen studies were found in the databases, and 6 of them met the qualifications. The results of this meta-analysis suggested that mothers with female baby (OR= 1.25; 95% CI: 1.20–1.31), with a previous history of HG (OR= 5.38; 95% CI: 1.10–26.36), multiparity (OR = 1.07; 95% CI: 0.94–1.22), with more than 1 fetus (OR= 2.13; 95%CI: 1.95–2.33), and underweight (OR= 1.19; 95%CI: 1.10–1.28) have higher risk to HG compared to those with male baby, without previous history of HG, primipara, single fetus, and normal BMI respectively. In addition, smoking mothers have a lower risk of HG compared to those who have never had a cigarette (OR= 0.69; 95%CI: 0.31–1.54). Finally, it suggested that mothers with female baby, history of previous HG, multiparity, underweight, and multi-baby are risk factors of HG. Meanwhile, smoking is perceived to be protective factors of HG

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妊娠剧吐的危险因素:回顾性队列研究的荟萃分析

妊娠剧吐(Hyperemesis gravidarum, HG)是一种以妊娠期持续和严重的恶心和呕吐为特征的妊娠状况，它会导致脱水和体重减轻，需要大量的医疗护理和住院治疗。呕吐的研究在统计能力和概括性方面受到限制，这是基于设施和规模相对较小的结果。本研究旨在探讨孕妇汞中毒的相关因素。它系统地审查在PubMed、EMBASE和Science Direct数据库中发表的文章。使用Review Manager 5.3 (RevMan 5.3)进行统计分析。在数据库中发现了318项研究，其中6项符合条件。本荟萃分析的结果表明，生女婴的母亲(OR= 1.25;95% CI: 1.20-1.31)，既往有HG病史(OR= 5.38;95% CI: 1.10-26.36)，多胎(OR = 1.07;95% CI: 0.94-1.22)， 1个以上胎儿(OR= 2.13;95%CI: 1.95-2.33)和体重过轻(OR= 1.19;95%CI: 1.10-1.28)发生HG的风险分别高于男婴、无HG史、初产妇、单胎和BMI正常的孕妇。此外，与从不吸烟的母亲相比，吸烟母亲患汞的风险更低(OR= 0.69;95%置信区间:0.31—-1.54)。结果提示，女胎、既往HG史、多胎、体重过轻、多胎均为HG的危险因素，吸烟为HG的保护因素

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来源期刊

Malaysian Journal of Public Health Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： Malaysian Journal of Public Health Medicine (MJPHM) is the official Journal of Malaysian Public Health Physicians’ Association. This is an Open-Access and peer-reviewed Journal founded in 2001 with the main objective of providing a platform for publication of scientific articles in the areas of public health medicine. . The Journal is published in two volumes per year. Contributors are welcome to send their articles in all sub-discipline of public health including epidemiology, biostatistics, nutrition, family health, infectious diseases, health services research, gerontology, child health, adolescent health, behavioral medicine, rural health, chronic diseases, health promotion, public health policy and management, health economics, occupational health and environmental health.