Synthesis and Characterization of Cystathionine-y-lyase (CSE) Inhibitors 1-(1H-Tetrazol-5-yl)but-3-yn-1-amine

Abstract

Cystathionine-γ-lyase (CSE) 1-(1H-tetrazol-5-yl) but-3-yn-1-amine) is co-enzyme play an important role in in situ production of H2S. In this study, herein reported the synthesis of a new molecule, which is inhibitors of CSE. Hydrogen sulfide is a signaling molecule in the form of gas, also it modulates a large number of mammalian physiological processes. Cystathionine-γ-lyase (CSE) catalyzes hydrogen sulfide synthesis and is a target for modulating under pathophysiological conditions. CSE is inhibited by propargylglycine (PPG), thus this study disclosed that it is useful for CSE inhibitors in the treatment of diseases where CSE inhibition provides therapeutic advantage to the patient having the disease.