Effect of Cryoprocessing on Umbilical Cord Blood for Hematological Disorders

Abstract

Cellular therapies promise to become major therapeutic modalities of this new century. The hematopoietic restoration with umbilical cord blood transplant can be a useful source of hematopoietic stem cells for routine bone marrow reconstitution. Thus it can be used as an effective source of stem cells for the treatment of various hematological disorders like leukemia, thalessaemia, aplastic anemia and it also can be used to replace the damaged tissue in various pathological conditions like Parkinson’s disease, Alzheimer’s, osteoarthritis etc. The advantage of the umbilical cord blood transplant being, use of unrelated umbilical cord blood transplantation with upto 2 to 3 HLA mismatch (Wagner et al, 1996).