Extracellular vesicles and particles as mediators of long-range communication in cancer: connecting biological function to clinical applications.

IF 25.7 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Gastroenterology Pub Date : 2023-09-01 Epub Date: 2023-08-16 DOI:10.20517/evcna.2023.37
Tetsuhiko Asao, Gabriel Cardial Tobias, Serena Lucotti, David R Jones, Irina Matei, David Lyden
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引用次数: 0

Abstract

Over the past decade, extracellular vesicles and particles (EVPs) have emerged as critical mediators of intercellular communication, participating in numerous physiological and pathological processes. In the context of cancer, EVPs exert local effects, such as increased invasiveness, motility, and reprogramming of tumor stroma, as well as systemic effects, including pre-metastatic niche formation, determining organotropism, promoting metastasis and altering the homeostasis of various organs and systems, such as the liver, muscle, and circulatory system. This review provides an overview of the critical advances in EVP research during the past decade, highlighting the heterogeneity of EVPs, their roles in intercellular communication, cancer progression, and metastasis. Moreover, the clinical potential of systemic EVPs as useful cancer biomarkers and therapeutic agents is explored. Last but not least, the progress in EVP analysis technologies that have facilitated these discoveries is discussed, which may further propel EVP research in the future.

细胞外囊泡和颗粒作为癌症远距离通讯的媒介:将生物功能与临床应用联系起来。
过去十年来,细胞外囊泡和颗粒(EVPs)已成为细胞间通讯的重要媒介,参与了许多生理和病理过程。在癌症方面,EVPs 可产生局部效应,如增加侵袭性、运动性和肿瘤基质的重编程,也可产生全身效应,包括转移前生态位的形成、决定器官向性、促进转移和改变各种器官和系统(如肝脏、肌肉和循环系统)的平衡。本综述概述了过去十年 EVP 研究的重要进展,强调了 EVP 的异质性及其在细胞间通讯、癌症进展和转移中的作用。此外,还探讨了系统性 EVP 作为有用的癌症生物标记物和治疗药物的临床潜力。最后但并非最不重要的一点是,讨论了促进这些发现的 EVP 分析技术的进步,这可能会进一步推动未来的 EVP 研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Gastroenterology
Gastroenterology 医学-胃肠肝病学
CiteScore
45.60
自引率
2.40%
发文量
4366
审稿时长
26 days
期刊介绍: Gastroenterology is the most prominent journal in the field of gastrointestinal disease. It is the flagship journal of the American Gastroenterological Association and delivers authoritative coverage of clinical, translational, and basic studies of all aspects of the digestive system, including the liver and pancreas, as well as nutrition. Some regular features of Gastroenterology include original research studies by leading authorities, comprehensive reviews and perspectives on important topics in adult and pediatric gastroenterology and hepatology. The journal also includes features such as editorials, correspondence, and commentaries, as well as special sections like "Mentoring, Education and Training Corner," "Diversity, Equity and Inclusion in GI," "Gastro Digest," "Gastro Curbside Consult," and "Gastro Grand Rounds." Gastroenterology also provides digital media materials such as videos and "GI Rapid Reel" animations. It is abstracted and indexed in various databases including Scopus, Biological Abstracts, Current Contents, Embase, Nutrition Abstracts, Chemical Abstracts, Current Awareness in Biological Sciences, PubMed/Medline, and the Science Citation Index.
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