Diphoterine for Chemical Burns of the Skin: A Systematic Review

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-02-02 DOI:10.3390/ebj4010006

Felicia Dinesen, Pernille Pape, M. Vestergaard, L. Rasmussen

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引用次数: 2

Abstract

The incidence of chemical burns appears to be increasing. Diphoterine is an amphoteric, chelating, polyvalent solution used for the decontamination of chemical splashes. In this systematic review, we aimed to assess the effect of diphoterine on chemical burns compared with water or no treatment. The primary endpoint was the depth of burn, and secondary outcomes included pain, duration of hospitalization, time to return to work, need for surgery, pH, and complications. PubMed, Embase, Cochrane Library, Web of Science, and Google Scholar were systematically searched using the terms “Diphoterine”, “Previn”, and ““Amphoteric solution” AND “burn””. A total of nine studies were included. One study evaluated the depth of chemical burns and found no difference between the diphoterine group and the control group. Four studies reported on pain, three of which found a more pronounced decrease in pain when using diphoterine compared to the control groups. Two studies found a significant neutralization of pH when using diphoterine. No differences were found for the remaining endpoints. Based on the very low certainty of evidence, this systematic review reports no observed difference between diphoterine and water or no treatment on the depth of a chemical burn. Diphoterine appeared to be associated with less pain and to have a neutralizing effect.

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双photerine治疗皮肤化学烧伤:系统综述

化学烧伤的发生率似乎在增加。二photerine是一种两性、螯合、多价溶液，用于清除化学溅污。在这篇系统综述中，我们的目的是评估二photerine对化学烧伤的影响，并与水或不处理进行比较。主要终点是烧伤深度，次要终点包括疼痛、住院时间、恢复工作时间、手术需求、pH值和并发症。系统地检索PubMed、Embase、Cochrane Library、Web of Science和Google Scholar，检索词为“Diphoterine”、“Previn”和“两性溶液”和“burn”。共纳入9项研究。一项研究评估了化学烧伤的深度，发现二photerine组和对照组之间没有差异。四项研究报告了疼痛，其中三项研究发现，与对照组相比，使用二photerine时疼痛的减轻更为明显。两项研究发现，当使用双蝶呤时，pH值有显著的中和作用。其余终点未发现差异。基于非常低的证据确定性，本系统评价报告没有观察到二磷蝶呤和水之间的差异，或者没有对化学烧伤的深度进行处理。双photerine似乎与疼痛减轻有关，并具有中和作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.