Omega-3 fatty acid nanocarriers: Characterization and potential applications

IF 7.9 2区化学 Q1 CHEMISTRY, PHYSICAL

Current Opinion in Colloid & Interface Science Pub Date : 2023-10-01 DOI:10.1016/j.cocis.2023.101728

Anan Yaghmur , Sana Ghayas , Habibullah Jan , Gokce Dicle Kalaycioglu , S. Moein Moghimi

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引用次数: 0

Abstract

Lyotropic non-lamellar liquid crystalline (LLC) nano-self-assemblies (including cubosomes and hexosomes) are attractive versatile platforms for the encapsulation and delivery of drugs and nutritional molecules. This is due to their unique structural features and architectural arrangements that afford loading of small molecules and macromolecules having different physicochemical properties with high efficiency. Considering the reported health-promoting effects of long-chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and their precursors ω-3 PUFA monoacylglycerols; here, we focus on physicochemical and biological properties of a new family of non-lamellar LLC nanoparticles assembled either from binary mixtures of phosphatidylglycerol and three types of ω-3 PUFAs, or from single ω-3 PUFA monoacylglycerols. We discuss recent progress in understanding their complexity, pH sensitivity, and structural tunability, as well as highlight their potential applications in health and medicine.

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Omega-3脂肪酸纳米载体:表征和潜在的应用

溶性非层状液晶(LLC)纳米自组装体(包括立方体体和自旋体)是药物和营养分子封装和输送的有吸引力的多功能平台。这是由于它们独特的结构特征和结构安排，可以高效地装载具有不同物理化学性质的小分子和大分子。考虑到已报道的长链ω-3多不饱和脂肪酸(ω-3 PUFAs)及其前体ω-3 PUFA单酰基甘油的健康促进作用;在这里，我们重点研究了一个新的非层状LLC纳米颗粒家族的物理化学和生物学特性，这些纳米颗粒要么是由磷脂酰甘油和三种ω-3 PUFA的二元混合物组装而成，要么是由单一ω-3 PUFA单酰基甘油组装而成。我们讨论了在理解它们的复杂性、pH敏感性和结构可调性方面的最新进展，并强调了它们在健康和医学方面的潜在应用。

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来源期刊

Current Opinion in Colloid & Interface Science 化学-物理化学

CiteScore

16.50

自引率

1.10%

发文量

审稿时长

11.3 weeks

期刊介绍： Current Opinion in Colloid and Interface Science (COCIS) is an international journal that focuses on the molecular and nanoscopic aspects of colloidal systems and interfaces in various scientific and technological fields. These include materials science, biologically-relevant systems, energy and environmental technologies, and industrial applications. Unlike primary journals, COCIS primarily serves as a guide for researchers, helping them navigate through the vast landscape of recently published literature. It critically analyzes the state of the art, identifies bottlenecks and unsolved issues, and proposes future developments. Moreover, COCIS emphasizes certain areas and papers that are considered particularly interesting and significant by the Editors and Section Editors. Its goal is to provide valuable insights and updates to the research community in these specialized areas.