Manufacturing of the Eriedescent Sterilizing Device

IF 1 Q4 ENGINEERING, MANUFACTURING
A. Sharifbaev, R. Mamidi, M. R. Gottimukkula, M. Gacura, G. Vanderlaan, X. Ji, D. Piovesan
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引用次数: 0

Abstract

Beyond an exceptional human toll, one of the most evident impacts of the ongoing COVID-19 pandemic is that of disrupted supply chain dynamics. Lessons learned here might help ameliorate the ability of frontline workers to secure personal protective equipment (PPE) such as N95 filtering facepiece respirators (FFRs) to prevent similar issues in future pandemics. A related concern is FFR waste streams, and the ability to recycle N95s using chemical or physical germicidal methods would greatly contribute to lessening PPE scarcity and providing relief to overall supply chains for all essential services. Early in 2020, the U.S. Food and Drug Administration (FDA) issued official guidance for sterilizers, disinfectant devices, and air purifiers with regards to the COVID-19 pandemic as a public health emergency bulletin. This guidance provided nonbinding recommendations for PPE and FFR decontamination processes, involving a wide spectrum of chemical and physical methods of sterilization. Many of the sterilization methods employ high heat or utilize polar chemical disinfectants that can compromise either the physical structure or the electrostatic properties of FFR fibers, thus attenuating the overall protection provided to the frontline worker. Ultraviolet germicidal irradiation (UVGI) has been employed for nearly a century to sterilize instruments and whole environments. UVGI offers numerous advantages as it is transitory by nature, leaving no chemical residue on the treated artifact. UVGI is also rapid, and depending on illumination sources, UVGI can easily scale to provide coverage to large areas. Here we provide an analysis of the regulatory aspect related to the use of UVC devices and describe our engineered design of a cost-efficient sterilization chamber that utilizes UVC for decontamination. Our design stresses a low-cost price point to facilitate easy manufacture for not only rapid deployment but also minimal impacts on supply chains. The device is intended to be easy to use, without any specialized training, and thus targets the general public for sanitizing non-washable materials, including PPE, FFR and other potential fomites, including electronic devices of daily use, that otherwise might harbor bacterial, viral and fungal pathogens.
灭菌装置的制造
除了巨大的人员伤亡外,持续的COVID-19大流行最明显的影响之一是供应链动态中断。在此吸取的经验教训可能有助于提高一线工作人员获得个人防护装备(PPE)的能力,如N95过滤式面罩呼吸器,以防止未来大流行中出现类似问题。一个相关的问题是FFR废物流,使用化学或物理杀菌方法回收n95的能力将大大有助于减少个人防护装备的短缺,并为所有基本服务的整体供应链提供救济。2020年初,美国食品药品监督管理局(FDA)发布了针对新冠肺炎大流行的消毒剂、消毒设备和空气净化器的官方指南,作为公共卫生紧急公告。本指南为个人防护装备和FFR去污过程提供了非约束性建议,涉及广泛的化学和物理灭菌方法。许多灭菌方法采用高温或使用极性化学消毒剂,这可能损害FFR纤维的物理结构或静电特性,从而削弱对一线工作人员的整体保护。近一个世纪以来,人们一直使用紫外线杀菌照射(UVGI)对仪器和整个环境进行灭菌。UVGI具有许多优点,因为它本质上是短暂的,在处理过的工件上不会留下化学残留物。UVGI也是快速的,并且根据照明光源,UVGI可以很容易地扩展以提供大面积的覆盖。在这里,我们提供了与UVC设备使用相关的监管方面的分析,并描述了我们利用UVC进行净化的成本效益灭菌室的工程设计。我们的设计强调低成本的价格点,以便易于制造,不仅可以快速部署,而且对供应链的影响最小。该设备旨在易于使用,无需任何专门培训,因此针对一般公众消毒不可洗涤材料,包括PPE, FFR和其他潜在污染物,包括日常使用的电子设备,否则可能含有细菌,病毒和真菌病原体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Micro and Nano-Manufacturing
Journal of Micro and Nano-Manufacturing ENGINEERING, MANUFACTURING-
CiteScore
2.70
自引率
0.00%
发文量
12
期刊介绍: The Journal of Micro and Nano-Manufacturing provides a forum for the rapid dissemination of original theoretical and applied research in the areas of micro- and nano-manufacturing that are related to process innovation, accuracy, and precision, throughput enhancement, material utilization, compact equipment development, environmental and life-cycle analysis, and predictive modeling of manufacturing processes with feature sizes less than one hundred micrometers. Papers addressing special needs in emerging areas, such as biomedical devices, drug manufacturing, water and energy, are also encouraged. Areas of interest including, but not limited to: Unit micro- and nano-manufacturing processes; Hybrid manufacturing processes combining bottom-up and top-down processes; Hybrid manufacturing processes utilizing various energy sources (optical, mechanical, electrical, solar, etc.) to achieve multi-scale features and resolution; High-throughput micro- and nano-manufacturing processes; Equipment development; Predictive modeling and simulation of materials and/or systems enabling point-of-need or scaled-up micro- and nano-manufacturing; Metrology at the micro- and nano-scales over large areas; Sensors and sensor integration; Design algorithms for multi-scale manufacturing; Life cycle analysis; Logistics and material handling related to micro- and nano-manufacturing.
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