Endometrial Scratching Effect on Pregnancy Rate in Intrauterine Insemination Cycles: A Randomized Controlled Trial

IF 0.8 Q4 REPRODUCTIVE BIOLOGY
Mina Naghi Jafarabadi, M. Bagheri, Z. Ebrahimi, M. Shariat, F. Haghollahi
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引用次数: 4

Abstract

Objectives : This study was aimed to examine the endometrial scratch injury effect to improve pregnancy rate in women undergoing intrauterine insemination (IUI). Materials and Methods: This randomized controlled clinical trial was conducted in a University Clinic from November 2017 to January 2019. A total of 120 candidates entered the study, who were assigned to intervention (n=60) and control (n=60) groups. All subjects underwent controlled ovarian stimulation using letrozole 2.5 mg/BD on a day between 3 and 7 of the cycle. Then, the sonographic monitoring was started from day 8 of the cycles, followed by injecting human chorionic gonadotropins (HCG) 100001U intramuscularly when 1-2 follicles reached 18 mm in diameter. Approximately 36-38 hours afterward, IUI was done and a B-HCG test was performed after 15 days as well. In addition, luteal phase support was performed with the vaginal progesterone 400 mg twice daily for 15 days. In the intervention group, on day 3 of the cycle endometrial cavity on the posterior wall was scratched with the vaginal cannula No. 4 by a single infertility specialist in addition to the routine procedure. The chemical and clinical pregnancy rates were the main outcome measurements. Results: The overall clinical pregnancy rates were 11/59 (18.6%) and 10/59 (16.9%) in intervention and control groups, respectively (P=0.810). Further, the abortion rates were 1/59 (1.7%) and 3/59 (5.1%) in intervention and control groups, respectively (P=0.303). Eventually, no cases of ectopic pregnancy were observed in either group. Conclusions: Based on the findings of this study, endometrial scratch by pipelle cannot improve pregnancy rate in the early proliferative phase.
子宫内膜划伤对宫内授精周期妊娠率的影响:一项随机对照试验
目的:探讨子宫内膜划伤对宫内人工授精(IUI)妇女提高受孕率的影响。材料与方法:该随机对照临床试验于2017年11月至2019年1月在一所大学诊所进行。共有120名候选人进入研究,他们被分为干预组(n=60)和对照组(n=60)。所有受试者在月经周期的第3 - 7天使用来曲唑2.5 mg/BD进行卵巢控制刺激。从周期第8天开始超声监测,1-2个卵泡直径达到18 mm时肌内注射人绒毛膜促性腺激素(HCG) 100001U。大约36-38小时后,进行人工授精,15天后进行B-HCG测试。此外,黄体期支持使用阴道黄体酮400mg,每天两次,持续15天。在干预组,在周期的第3天,除常规程序外,由一名不孕专家用阴道4号套管刮擦后壁子宫内膜腔。化学妊娠率和临床妊娠率是主要的结局指标。结果:干预组临床总妊娠率为11/59(18.6%),对照组为10/59(16.9%),差异有统计学意义(P=0.810)。干预组流产率为1/59(1.7%),对照组流产率为3/59 (5.1%)(P=0.303)。最终,两组均未发现异位妊娠。结论:根据本研究结果,导管划伤子宫内膜不能提高早期增殖期的妊娠率。
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来源期刊
CiteScore
1.60
自引率
14.30%
发文量
8
期刊介绍: All kind of knowledge contributing to the development of science by its content, value, level and originality will be covered by IJWHR. Problems of public health and their solutions are at the head of the windows opening us to the world. The "International Journal of Women''s Health and Reproduction Sciences” is a modern forum for scientific communication, covering all aspects women health and reproduction sciences, in basic and clinical sciences, mainly including: -Medical Education in Women Health and Reproduction Sciences -Cardiology in Women Health-Related Reproductive Problems -Sports Medicine in Women Health and Reproduction Sciences -Psychiatry in Women Health-Related Reproductive Problems -Antioxidant Therapy in Reproduction Medicine Sciences -Nutrition in Women Health and Reproduction Sciences -Defense Androgen and Estrogen -Fertility and Infertility -Urogynecology -Endometriosis -Endocrinology -Breast Cancer -Menopause -Puberty -Eroticism -Pregnancy -Preterm Birth -Vaginal Diseases -Sex-Based Biology -Surgical Procedures -Nursing in Pregnancy -Obstetrics/Gynecology -Polycystic Ovary Syndrome -Hyperandrogenism in Females -Menstrual Syndrome and Complications -Oncology of Female Reproductive Organs -Traditional Medicine in Women Reproductive Health -Ultrasound in Women Health Reproduction sciences -Stem Cell Research In Women Reproduction Sciences -Complementary Medicine in Women Reproductive Health -Female Sexual Dysfunction: Pathophysiology & Treatment
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