Peniciisoquinoline A: A new tetrahydroisoquinoline from mangrove-derived fungus Penicillium sp. DM27

Journal of Holistic Integrative Pharmacy Pub Date : 2022-09-01 DOI:10.1016/S2707-3688(23)00046-8

Liming HE , Zifang ZHAO , Mengke ZHANG , Zhijie XIANG , Kui HONG , Fengkai FAN , Yousheng CAI

{"title":"Peniciisoquinoline A: A new tetrahydroisoquinoline from mangrove-derived fungus Penicillium sp. DM27","authors":"Liming HE , Zifang ZHAO , Mengke ZHANG , Zhijie XIANG , Kui HONG , Fengkai FAN , Yousheng CAI","doi":"10.1016/S2707-3688(23)00046-8","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>This study aims to search for structurally novel, natural bioactive products from mangrove-derived fungi.</p></div><div><h3>Methods</h3><p>Compounds were isolated and purified by column chromatography on HP20 macroreticular resin, silica gel, Sephadex LH-20 gel, and high performance liquid chromatography. The structures of the isolates were analyzed using NMR and MS data, and the absolute configuration of <strong>1</strong> was determined by calculated ECD spectroscopic methods. The cytotoxicity of all the isolates was tested against HCT-116, HepG2, HEK 293t, and 5637 cancer cell lines using CCK-8 assay.</p></div><div><h3>Results</h3><p>A new tetrahydroisoquinoline named peniciisoquinoline A <strong>(1)</strong> was obtained from <em>Penicillium</em> sp. DM27 along with five known compounds. Peniciisoquinoline A <strong>(1)</strong> was inactive against the four cancer cell lines.</p></div><div><h3>Conclusion</h3><p>This study conducted chemical research on <em>Penicillium</em> sp. DM27 and tested the cytotoxic activity of the new alkaloid <strong>(1),</strong> which will assist in the further development and utilization of mangrove-derived fungi.</p></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"3 3","pages":"Pages 248-254"},"PeriodicalIF":0.0000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2707368823000468/pdfft?md5=750fee5096bb11e37d8a0bf7a0f1b6cb&pid=1-s2.0-S2707368823000468-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Holistic Integrative Pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2707368823000468","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

This study aims to search for structurally novel, natural bioactive products from mangrove-derived fungi.

Methods

Compounds were isolated and purified by column chromatography on HP20 macroreticular resin, silica gel, Sephadex LH-20 gel, and high performance liquid chromatography. The structures of the isolates were analyzed using NMR and MS data, and the absolute configuration of 1 was determined by calculated ECD spectroscopic methods. The cytotoxicity of all the isolates was tested against HCT-116, HepG2, HEK 293t, and 5637 cancer cell lines using CCK-8 assay.

Results

A new tetrahydroisoquinoline named peniciisoquinoline A (1) was obtained from Penicillium sp. DM27 along with five known compounds. Peniciisoquinoline A (1) was inactive against the four cancer cell lines.

Conclusion

This study conducted chemical research on Penicillium sp. DM27 and tested the cytotoxic activity of the new alkaloid (1), which will assist in the further development and utilization of mangrove-derived fungi.

查看原文本刊更多论文

青霉异喹啉A:一种新的四氢异喹啉，来源于红树真菌青霉菌

目的从红树林衍生真菌中寻找结构新颖的天然生物活性产物。方法采用HP20大孔树脂柱层析、硅胶柱层析、Sephadex LH-20凝胶柱层析和高效液相层析对化合物进行分离纯化。利用核磁共振和质谱分析了分离物的结构，利用计算ECD方法确定了1的绝对构型。采用CCK-8法检测各分离株对HCT-116、HepG2、HEK 293t和5637癌细胞的细胞毒性。结果从Penicillium sp. DM27中分离得到一种新的四氢异喹啉，命名为peniciisoquinoline A(1)。青霉素异喹啉A(1)对四种癌细胞均无活性。结论本研究对红树源真菌青霉菌DM27进行了化学研究，并检测了其细胞毒活性(1)，为红树源真菌的进一步开发利用提供了依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Holistic Integrative Pharmacy

自引率

0.00%

发文量