Histological examination of the role of Vitamin E in cyclophosphamide-induced testicular damage in rats

Abstract

Cyclophosphamide is among anticancer and immunosuppressing drugs frequently used in chemotherapy treatment. Cyclophosphamide is a chemotherapeutic agent but has also toxic effect on testes. Testicular cells can be protected from toxic effects by antioxidant systems, including vitamin E. The aim of this study is to reveal what kind of an effect the vit-E exerts upon the experimentally induced CP toxicity on testicular tissue of rats. Results of the present study indicate that the testicular injury induced by CP can be prevented by administration of vitamin E.