Deletion of the 19kDa antigen does not alter the protective efficacy of BCG

V.V. Yeremeev , G.R. Stewart , O. Neyrolles , K. Skrabal , V.G. Avdienko , A.S. Apt , D.B. Young
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引用次数: 29

Abstract

Expression of the Mycobacterium tuberculosis 19kDa lipoprotein in saprophytic mycobacteria has been found to reduce their ability to prime a protective response to subsequent virulent challenge in the mouse model. The present study was designed to test whether 19kDa expression has an analogous detrimental effect on the efficacy of BCG vaccination. In contrast to the results in saprophytes, neither overexpression of the 19kDa antigen, nor deletion of the endogenous 19kDa gene altered the ability of BCG to protect against M. tuberculosis challenge in a mouse model.

19kDa抗原的缺失不会改变卡介苗的保护作用
在小鼠模型中,腐生分枝杆菌中结核分枝杆菌19kDa脂蛋白的表达降低了它们对随后的毒性攻击产生保护性反应的能力。本研究旨在测试19kDa的表达是否对卡介苗接种的效果有类似的有害影响。与腐生植物的结果相反,在小鼠模型中,19kDa抗原的过表达和内源性19kDa基因的缺失都不会改变卡介苗抵抗结核分枝杆菌攻击的能力。
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