Immunomodulatory Activity of Gymnema sylvestre Leaves

Abstract

To study the immunomodulatory property of the leaves of Gymnema sylvestre R.Br. (Asclepiadaceae). In our present study, the aqueous extract of Gymnema sylvestre leaves was investigated for immunomodulatory activity by assessing Neutrophil locomotion and chemotaxis test, phagocytosis of killed Candida albicans and Nitroblue terazolium tests. The extract was given at does of 10 μg/ml, 25μg/ml, 50μg/ml, 100μg/ml and 1000μg/ml. Results of in-vitro immunomodulatory activity lead to the conclusion that the aqueous extract of Gymnema sylvestre showed predominantly significant activity on in-vitro human neutrophils in all parameters, which is compared to the standard.