Relationship of oral candidiasis with salivary lysozyme and lactoferrin in HIV-positive patients: a systematic review

IF 0.3 Q4 INFECTIOUS DISEASES
P. Motahari
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引用次数: 0

Abstract

Oral candidiasis is one of the main consequences of human immunodeficiency virus (HIV) infection. Saliva contains proteins that play a key role in the health of oral cavity. The aim of this review study was to investigate the relationship of oral candidiasis with salivary lysozyme and lactoferrin in patients with HIV infection. In this systematic review study, all articles with English abstract were searched with the keywords of “Oral Candidiasis” or “Candida” and “Saliva” and “HIV” or “AIDS” and “Lysozyme” and “Lactoferrin” from the Google Scholar, PubMed, Web of Science, Cochrane, and Scopus databases from 1990 until April 2020. Amongst the 16 articles obtained after reviewing the abstracts, 13 appropriate articles were included in this study. In 11 studies, the relationship between salivary lactoferrin and oral candidiasis was investigated, 54% of which showed an increase in salivary lactoferrin in HIV-positive patients with candidiasis. Eight studies examined the relationship between salivary lysozyme and oral candidiasis, 63% of which showed no association. Understanding numerous factors and conditions involved in candida cloning would be broadly related to increasing our understanding of fungal pathogenesis and host defense factors. The results of our study could be useful in diagnosing and designing new strategies for the prevention and treatment of fungal infections in HIV-positive patients. In addition to anti-fungal properties, non-toxicity to human cells could lead to lactoferrin being used in the future as a drug to prevent and treat fungal infections in patients with immunity difficulties. HIV AIDS Rev 2021; 20, 1: 17-20 DOI: https://doi.org/10.5114/hivar.2021.105091
hiv阳性患者口腔念珠菌病与唾液溶菌酶和乳铁蛋白的关系:一项系统综述
口腔念珠菌病是人类免疫缺陷病毒(HIV)感染的主要后果之一。唾液中含有对口腔健康起关键作用的蛋白质。本综述旨在探讨HIV感染患者口腔念珠菌病与唾液溶菌酶和乳铁蛋白的关系。本系统综述研究以“Oral Candidiasis”或“Candida”和“唾液”、“HIV”或“AIDS”和“Lysozyme”和“乳铁蛋白”为关键词检索自1990年至2020年4月的Google Scholar、PubMed、Web of Science、Cochrane和Scopus数据库中所有带英文摘要的文章。在查阅摘要后获得的16篇文章中,有13篇合适的文章被纳入本研究。有11项研究调查了唾液乳铁蛋白与口腔念珠菌病的关系,其中54%的研究显示hiv阳性念珠菌病患者唾液乳铁蛋白升高。八项研究调查了唾液溶菌酶和口腔念珠菌病之间的关系,其中63%的研究显示没有关联。了解念珠菌克隆中涉及的许多因素和条件将广泛地关系到我们对真菌发病机制和宿主防御因素的理解。我们的研究结果可能有助于诊断和设计预防和治疗hiv阳性患者真菌感染的新策略。除了抗真菌的特性,对人体细胞的无毒性可能导致乳铁蛋白在未来被用作预防和治疗免疫困难患者真菌感染的药物。HIV / AIDS Rev 2021;DOI: https://doi.org/10.5114/hivar.2021.105091
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
HIV & AIDS Review
HIV & AIDS Review INFECTIOUS DISEASES-
CiteScore
0.50
自引率
0.00%
发文量
30
审稿时长
12 weeks
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