Cytotoxicity of Heterophyllene A, the Derivative of Arylbenzofuran from Stem Bark of Artocarpus calophylla

Abstract

: Exploration of secondary metabolites was the focus of this research, especially of Artocarpus calophylla species to look for a potential cytotoxic agent. An arylbenzofuran derivative compound, namely heterophyllene A was isolated from the stem bark of Artocarpus calophylla . Structure determination of this compound has been elucidated using UV-Vis spectroscopy, 1D, and 2D NMR analysis. This compound has a lower IC 50 than ethyl acetate extract. The IC 50 of this compound (57,54 µg/mL) to HeLa and (25,80 µg/mL) to T47D cells, ethyl acetate extract (>100 µg/mL) to HeLa and (84,16 µg/mL) to T47D cells.