Association between Zinc transporter genes ZIP11 rs11077654 polymorphism with bladder cancer risk in Chinese Han Population

Abstract

Objective

To study the association between Zinc transporter genes ZIP11 rs11077654 polymorphism with bladder cancer risk in Chinese Han Population.

Methods

A total of 307 unrelated Chinese Han descent, including 139 bladder cancer patients as bladder cancer group and 168 healthy people as healthy control group were studied. The ZIP11 rs11077654 loci was analyzed by Polymerase Chain Reaction (PCR) and its relationship with bladder cancer was analyzed.

Results

There were three kinds of genotypes in ZIP11 gene rs11077654 loci (CC, CA and AA). Our analysis presented that the CA genotype was not associated with bladder cancer risk when the CC genotype may be served as reference (OR, 1.355; 95% CI, 0.750–2.451; p = 0.313). We combined CA and AA genotypes as a dominant genetic model. There was no significant association with bladder cancer risk as well in the combined group (OR, 1.333; 95% CI, 0.758–2.343; p = 0.317). There was no significant association observed between the CA/AA genotypes and low-grade (OR, 0.900; 95% CI, 0.411–1.973; p = 0.793) or high-grade bladder cancer (OR, 0.675; 95% CI, 0.349–1.308; p = 0.243), and nor between the CA/AA genotypes and NMIBC (OR, 0.636; 95% CI, 0.334–1.213; p = 0.167) or MIBC (OR, 1.100; 95% CI, 0.478–2.531; p = 0.823).

Conclusion

The rs11077654 of ZIP11 gene was not associated with bladder cancer in Chinese Han Population.