Making Hydrogel with Crosslinked Reactions between Chitosan and Dialdehyide Cellulose from Coconut Fiber as Wound Healers

Abstract

: Making hydrogels from crosslinked reactions between cellulose oxidized with chitosan through Schiff base formation reaction has been investigated as a wound healing drug in vivo. α-Cellulose obtained from the isolation of coconut fiber by 14.24 g. α-Cellulose is oxidized by using KIO 4 to be dialdehyde cellulose. The degree of oxidation of cellulose dialdehyde is 86%. Hydrogels were made by schiff base crosslinking reaction between chitosan and dialdehyde cellulose with temperature variations of 75, 100, 125 and 150 oC. The optimum temperature in hydrogel synthesis is 100 oC. the formation of a hydrogel is supported by the presence of FTIR Spectrophotometer where the spectrum of 1643.35 cm-1 is formed where the group -C=N- which shows the formation of a Schiff base reaction. The hydrogel that is obtained has a good swelling ability of more than 1000%. Invivo analysis was carried out for 7 days in mice and as a result, the injured mice have recovered and have not left a mark.