Influence of chronic alcoholic intoxication and lighting regime on karyometric and ploidometric parameters of hepatocytes of rats

IF 2.1 4区生物学 Q2 Agricultural and Biological Sciences

Caryologia Pub Date : 2021-11-28 DOI:10.36253/caryologia-1122

D. Areshidze, Y. Kirillov, L. Makartseva, M. Kozlova, I. Chernov, E. Shtemplevskaya

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Abstract

The features of the diurnal dynamics of the area of rat hepatocyte nuclei and their ploidy were studied under conditions of a standart (fixed) light regime and constant illumination, as well as under chronic exposure to alcohol in the mentioned light regimes. It has been shown that exposure to alcohol and exposure to constant illumination separately lead to a change in the amplitude-phase characteristics of the circadian rhythm of the nucleus area, while the combined effect of these factors leads to a complete destruction of the rhythm, which indicates a violation of adaptation processes. An increase in the average ploidy of hepatocyte nuclei in chronic alcohol intoxication is also shown, while in animals kept under constant illumination without drinking alcohol, the values of this parameter decrease, which indicates a successful course of the adaptation process. The conducted research indicates that the results of karyometric and ploidometric analysis characterize the degree of influence of alcohol intoxication and changes in the light regime on the liver of rats, reflecting the rate of efficiency of adaptation to these factors.

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慢性酒精中毒及光照对大鼠肝细胞核倍体参数的影响

在标准(固定)光照和恒定光照条件下，以及在上述光照条件下长期暴露于酒精下，研究了大鼠肝细胞核区域的昼夜动力学特征及其倍性。研究表明，暴露于酒精和暴露于持续照明分别导致核区昼夜节律的振幅-相位特征发生变化，而这些因素的综合作用导致节律完全破坏，这表明适应过程受到破坏。慢性酒精中毒时，肝细胞核的平均倍性增加，而在不饮酒的持续光照下，该参数的值降低，这表明适应过程成功。本研究表明，核测定和倍体测定的结果表征了酒精中毒对大鼠肝脏的影响程度和光照制度的变化，反映了对这些因素的适应效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Caryologia 生物-遗传学

CiteScore

1.60

自引率

23.80%

发文量

审稿时长

12 months

期刊介绍： Caryologia is devoted to the publication of original papers, and occasionally of reviews, about plant, animal and human karyological, cytological, cytogenetic, embryological and ultrastructural studies. Articles about the structure, the organization and the biological events relating to DNA and chromatin organization in eukaryotic cells are considered. Caryologia has a strong tradition in plant and animal cytosystematics and in cytotoxicology. Bioinformatics articles may be considered, but only if they have an emphasis on the relationship between the nucleus and cytoplasm and/or the structural organization of the eukaryotic cell.