Ths Study on the Prevention of Angialgia induced by the High osmotic Pressure of Peripheral Parenteral Nutrition Infusions: Influence on the Infusion System Using Tandem Method.

Abstract

A study on the prevention of angialgia induced by the high osmotic pressure of Peripheral Parenteral Nutrition infusion: Influence on the infusion system using Tandem method.During peripheral parenteral nutrition (PPN) infusions, angialgia more frequently occures than during other types of peripheral infusion. This is probably caused by the low pH, infusion speed and high osmotic pressure of PPN. We hypothesized that we could prevent angialgia by attenuating the osmotic pressures during PPN infusion. We therefore attempted examinations using the Tandem method as follows; It was possible to control the osmotic pressure in the effuent solution by changing the joining method of these infusions, thus suggesting that the specific gravity of these infusions affected the osmotic pressure.Specifically, we connected a hypotonic infusions (e.q., Soldem-3 A) with a low specific gravity to a PPN infusion (e.q., Amicaliq) with a high specific gravity, and the osmotic pressure of the effluent solution was maintained at a high level during the first 15 min, but thereafter gradually decreased. On the other hand, We connected a PPN infusion to a hypotonic infusion, and thus were able to maintain a low and constant osmotic pressure in the effluent solution.These results suggest that the Tandem method is useful in preventing angialgia due to the high osmotic pressure of PPN infusion. PPN infusion should thus be connected to a hypotonic infusion that has a lower specific gravity than that of the PPN infusion.