Skin Penetration of Coenzyme Q10 in Nanostructure Lipid Carriers Using Olive Oil and Cetyl Palmitate

Abstract

Penetration is an absolute requirement for active ingredient to produce an effect in deep of the skin. First obstacle for active ingredient to penetrate through the skin is stratum corneum. Nanotechnology that has nano size particles, is the answer to make it’s penetrate through the skin. In this research the skin penetration of Coenzyme Q10 was loaded in the lipid nanoparticles that is nanostructure lipid carrier (NLC) was compered with it was dissolved in olive oil. The research result known that Coenzyme Q10 was loaded in NLC has deeper penetration (639.34 ± 17.69 μm) in the mice skin than it was dissolved in olive oil as control (33.00 ± 1.71 μm), its just least penetrated into the skin after 6 hours sample application.