Modulation of host immunity by haematophagous arthropods

Annals of Tropical Medicine & Parasitology Pub Date : 2001-12-01 DOI:10.1080/00034983.2001.11813695

G. Schoeler, S. Wikel

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引用次数: 9

Abstract

The medical and veterinary public-health importance of haematophagous arthropods is immense and continuing to increase because of the emergence of new vector-borne infectious agents and the resurgence of well known ones. Control of blood-feeding arthropods and the pathogens they transmit is compounded by drug, insecticide and acaricide resistance. Novel control strategies are needed. Immunological control is one very promising approach to these problems. In order to develop anti-arthropod vaccines that block pathogen transmission and establishment, the immunological interactions occurring at the interface of the blood-feeding arthropod and host must be characterized. An important component of these interactions is arthropod modulation of the host's innate and acquired, specific immune defences. This review discusses current knowledge regarding the ability of haematophagous arthropods to alter their hosts' immune defences, the impact of those changes on pathogen transmission, the molecular bases for the immunomodulation, and strategies for identification of the molecules in arthropod saliva that are responsible for the immunomodulation.

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噬血节肢动物对宿主免疫的调节

噬血节肢动物在医学和兽医公共卫生方面的重要性是巨大的，并且由于新的病媒传播传染原的出现和已知传染原的重新出现而继续增加。对血食性节肢动物及其传播的病原体的控制因药物、杀虫剂和杀螨剂耐药性而复杂化。需要新的控制策略。免疫控制是解决这些问题的一个很有希望的方法。为了开发阻断病原体传播和建立的抗节肢动物疫苗，必须对发生在吸血节肢动物和宿主界面的免疫相互作用进行表征。这些相互作用的一个重要组成部分是节肢动物对宿主先天和获得性特异性免疫防御的调节。本文综述了目前关于噬血节肢动物改变宿主免疫防御能力的知识，这些改变对病原体传播的影响，免疫调节的分子基础，以及鉴定节肢动物唾液中负责免疫调节的分子的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annals of Tropical Medicine & Parasitology

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