Association between the prevalence of obstructive lung disease and the use of aspirin in a diabetic population

Abstract

Background: Many diabetic patients take a daily low-dose of aspirin because they are two to three times more likely to suffer from heart attacks and strokes, but its role in obstructive lung diseases is less clear. Methods: A total of 1,003 subjects in community practice settings were interviewed at home. Patients self-reported their personal and clinical characteristics, including any history of obstructive lung disease (including COPD or asthma). Current medications were obtained by the direct observation of medication containers. We performed a cross-sectional analysis of the interviewed subjects to assess for a possible association between obstructive lung disease history and the use of aspirin. Results: In a multivariate logistic regression model, a history of obstructive lung disease was significantly associated with the use of aspirin even after correcting for potential confounders, including gender, low income (

分享

查看原文 本刊更多论文

糖尿病人群中阻塞性肺病患病率与阿司匹林使用之间的关系

背景:许多糖尿病患者每天服用低剂量阿司匹林，因为他们患心脏病和中风的可能性是糖尿病患者的两到三倍，但阿司匹林在阻塞性肺病中的作用尚不清楚。方法:对1003名社区实习对象进行家庭访谈。患者自我报告其个人和临床特征，包括任何阻塞性肺疾病史(包括COPD或哮喘)。目前的药物是通过直接观察药物容器获得的。我们对受访对象进行了横断面分析，以评估阻塞性肺病病史与阿司匹林使用之间可能存在的关联。结果:在一个多因素logistic回归模型中，即使校正了潜在的混杂因素，包括性别、低收入(< 30,000美元/年)、合病数量、药物数量、吸烟和酒精问题，阻塞性肺疾病史与阿司匹林的使用仍显著相关(调整后的优势比= 0.67,P = 0.03, 95%置信区间= 0.47,0.97)。服用阿司匹林和使用胰岛素的糖尿病患者的情况正好相反。另一项分析发现阿司匹林和胰岛素之间存在显著的相互作用:阿司匹林与较低的肺部疾病发病率相关，但同时服用两种药物的人群患病率明显较高。结论:这些数据表明，在糖尿病患者中，阿司匹林的使用与阻塞性肺疾病患病率呈负相关，而在使用胰岛素的患者中则没有。需要进一步的研究来确定这种联系是否有因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。