Study on properties of 3D-printed GelMA hydrogel scaffolds with different nHA contents

IF 2.1 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Yaocheng Wang, Chengxiong Lin
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引用次数: 0

Abstract

Biological 3D printing is a reliable technology for 3D printing bone repair scaffolds with simple operation, high efficiency, and relatively low cost. Gelatin methacryloyl (GelMA) hydrogels have attracted much attention due to their good biocompatibility, but the poor mechanical properties limit their application in bone reconstruction engineering. In this study, nano-hydroxyapatite (nHA) particles were added to GelMA hydrogels, and the performances of composite hydrogel scaffolds with different nHA contents were investigated in terms of rheological properties, light transmission properties, surface morphology, mechanical properties, and biocompatibility. The experimental results showed that the incorporation of nHA particles could effectively improve the printability and mechanical properties of the scaffolds, the scaffold fibers had better resistance to deformation, improved degradation rate, and biological experiments confirmed that nHA particles had no significant cytotoxicity. However, the addition of HA particles also reduced the light transmission properties of the slurry, and when its content exceeds a certain value, the hydrogel scaffolds show incomplete curing and eventually affect their test performance. The results can offer guidance and reference for the selection of ink and function for 3D printing bone repair scaffold.
不同nHA含量的3d打印凝胶支架性能研究
生物3D打印是一种可靠的3D打印骨修复支架技术,操作简单,效率高,成本相对较低。明胶甲基丙烯酰(GelMA)水凝胶因其良好的生物相容性而备受关注,但其较差的力学性能限制了其在骨重建工程中的应用。本研究将纳米羟基磷灰石(nHA)颗粒加入到GelMA水凝胶中,从流变性能、透光性、表面形貌、力学性能和生物相容性等方面考察了不同nHA含量的复合水凝胶支架的性能。实验结果表明,nHA颗粒的掺入可以有效提高支架的打印性和力学性能,支架纤维具有更好的抗变形能力,降解率提高,生物实验证实nHA颗粒无明显的细胞毒性。然而,HA颗粒的加入也降低了浆料的透光性能,当其含量超过一定值时,水凝胶支架呈现不完全固化,最终影响其试验性能。研究结果可为3D打印骨修复支架墨水和功能的选择提供指导和参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Bioactive and Compatible Polymers
Journal of Bioactive and Compatible Polymers 工程技术-材料科学:生物材料
CiteScore
3.50
自引率
0.00%
发文量
27
审稿时长
2 months
期刊介绍: The use and importance of biomedical polymers, especially in pharmacology, is growing rapidly. The Journal of Bioactive and Compatible Polymers is a fully peer-reviewed scholarly journal that provides biomedical polymer scientists and researchers with new information on important advances in this field. Examples of specific areas of interest to the journal include: polymeric drugs and drug design; polymeric functionalization and structures related to biological activity or compatibility; natural polymer modification to achieve specific biological activity or compatibility; enzyme modelling by polymers; membranes for biological use; liposome stabilization and cell modeling. This journal is a member of the Committee on Publication Ethics (COPE).
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