Swelling Behavior and Drug Release of Interpenetrating Network Composed of PVA and Chitosan

Abstract

PVA and chitosan biodegradable, non-toxic, biocompatible polymers convenient for use in drug release. In this study polyvinyl alcohol (PVA) and chitosan (CS) hydrogels crosslinked with glutaraldehyde (GA) with different ratio morphology and structure characterization interpenetrating polymer network (IPN).They were investigated by Fourier transmission infrared spectroscopy (FTIR), scanning electron microscope (SEM), UV-Visible spectrophotometer,swelling of hydrogel and drug release were studied by changing crosslinking ratio and PH.