Experimental evaluation of Yersinia pseudotuberculosis bacteria sensitivity to antimicrobial compositions based on copper nanoparticles in in vitro and in vivo experiments

Disinfection affairs Pub Date : 2023-03-01 DOI:10.35411/2076-457x-2023-1-5-23

G. Frolov, Abdulla Abumalik Abdukadirov ugli, I. Lundovskikh, Anna Yuryevna Mironina, K. I. Gurin, I. Pogorelsky, Aleksandr Victorovich Mironin, K. E. Gavrilov

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Abstract

The paper presents the results of the antibacterial efficacy of disinfecting compositions based on copper nanoparticles and its oxides in antiseptic solutions of cetylpyridinium chloride and benzalkonium chloride against the causative agent of pseudotuberculosis Y. pseudotuberculosis of in vitro and in vivo experiments. Using the bacteriological method and the results of electron microscopy, high bactericidal activity of disinfecting compositions has been proven. Anti-yersiniosis activity and safety of both compositions were revealed in experimental pseudotuberculosis of conventional white mice. Simultaneous oral administration of the compositions under study to experimental animals limits the initiation and development of the infectious process and prevents the death of laboratory animals. Possible mechanisms of enhancing the biocidal activity of the tested disinfecting compositions are considered. Keywords: pseudotuberculosis, microorganisms, biocidal activity, antiseptic, nanoparticles, zeta potential.

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假结核耶尔森菌对铜纳米颗粒抗菌组合物敏感性的体外和体内实验评价

本文介绍了铜纳米颗粒及其氧化物消毒组合物在氯化十六烷基吡啶和氯化苯扎氯铵防腐液中对致病菌假结核杆菌的体外和体内抑菌效果。利用细菌学方法和电子显微镜检查结果，证实了消毒组合物具有较高的杀菌活性。实验结果表明，两种组合物在常规小鼠假结核实验中抗耶尔森菌病的活性和安全性。将所研究的组合物同时口服给药给实验动物，限制了感染过程的开始和发展，并防止实验动物的死亡。考虑了提高所测消毒组合物的杀生物活性的可能机制。关键词:假结核，微生物，杀菌活性，防腐剂，纳米颗粒，zeta电位。

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Disinfection affairs

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