Honoring the work and life of Leroy C. Stevens. A symposium as part of the International Stem Cell Initiative Workshop.

C. Graham, D. Solter, J. Gearhart, J. Nadeau, B. Knowles
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Abstract

In 2016, a symposium was convened in Leroy C. Stevens' honor, in association with a meeting of the International Stem Cell Initiative (ISCI). ISCI, funded internationally, is composed of a group of ~100 scientists from many countries, under the leadership of Peter Andrews, who have worked together to characterize a significant number of human pluripotent stem cell lines, to monitor their genetic stability and their differentiation into mature cell types and tissues in vitro and in vivo. Those at the ISCI meeting puzzled through one of the thorniest problems in the therapeutic use of the differentiated derivatives of pluripotent stem cells for human therapy; namely, pluripotent stem cells can differentiate into any cell type in the adult organism, but they also have the capacity for unlimited self-renewal, hence if mutated they may have tumorigenic potential. The meeting considered how these cells might become genetically or epigenetically abnormal and how the safety of these cells for human therapeutic uses could be assessed and assured. The symposium was an opportunity to pay tribute to Leroy Stevens and to the basic science origins of this newest aspect of regenerative medicine. It was a time to reflect on the past and on how it can influence the future of our field.
纪念Leroy C. Stevens的工作和一生。国际干细胞倡议研讨会的一部分。
2016年,在Leroy C. Stevens的荣誉下,与国际干细胞倡议(ISCI)会议联合召开了一次研讨会。ISCI由来自多个国家的约100名科学家组成,在Peter Andrews的领导下,他们共同研究了大量人类多能干细胞系的特征,监测了它们的遗传稳定性以及它们在体外和体内向成熟细胞类型和组织的分化。参加ISCI会议的人对多能干细胞分化衍生物用于人类治疗的最棘手的问题之一感到困惑;也就是说,多能干细胞可以在成年生物体中分化成任何类型的细胞,但它们也具有无限自我更新的能力,因此,如果发生突变,它们可能具有致瘤潜力。会议审议了这些细胞如何在遗传或表观遗传上变得异常,以及如何评估和确保这些细胞用于人类治疗的安全性。这次研讨会是一次向Leroy Stevens致敬的机会,也是一次向再生医学这一最新领域的基础科学起源致敬的机会。这是一个反思过去以及它将如何影响我们这个领域未来的时刻。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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