Potassium channels in gastrointestinal smooth muscle

F. Vogalis
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引用次数: 67

Abstract

1 Electromechanical coupling in smooth muscle serves to coordinate the contractile activity of the syncytium. Electrical activity of smooth muscle of the gut is generated by ionic conductances that regulate and in turn are regulated by the membrane potential of smooth muscle cells. This activity determines the extent of Ca2+ entry into smooth muscle cells, and thus, the timing and intensity of contractions. 2 Potassium channels play an important role in regulating the excitability of the syncytium. The different types of K+ channel are characterized by different sensitivities to membrane potential, to intracellular Ca2+ levels and to modulation by agonists. 3 This review highlights the different types of K+ channels found in gut smooth muscle and describes their possible roles in regulating the electrical activity of the muscle.

胃肠道平滑肌中的钾通道
平滑肌中的机电耦合作用于协调合胞体的收缩活动。肠道平滑肌的电活动是由离子电导产生的,离子电导调节平滑肌细胞的膜电位,而离子电导又受平滑肌细胞的膜电位调节。这种活动决定了Ca2+进入平滑肌细胞的程度,从而决定了收缩的时间和强度。钾离子通道在合胞体兴奋性调节中起重要作用。不同类型的K+通道的特点是对膜电位、细胞内Ca2+水平和激动剂调节的敏感性不同。这篇综述强调了在肠道平滑肌中发现的不同类型的K+通道,并描述了它们在调节肌肉电活动中的可能作用。
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