K. Kojima, I. Kawahata, Hisanao Izumi, Sei-Ichi Yoshihara, K. Oki, K. Fukunaga
{"title":"Intranasal Administration of Conditioned Medium from Cultured Mesenchymal Stem Cells Improves Cognitive Impairment in Olfactory Bulbectomized Mice","authors":"K. Kojima, I. Kawahata, Hisanao Izumi, Sei-Ichi Yoshihara, K. Oki, K. Fukunaga","doi":"10.4236/aad.2020.93004","DOIUrl":null,"url":null,"abstract":"Alzheimer’s disease (AD) is the common cause of \ndementia which shows the neuro-pathologies like an accumulation of amyloid-β (Aβ) \nand degeneration of cholinergic neuron. Olfactory bulbectomized (OBX) mice show \nsome of AD features, so they have been used to research as AD model. \nMesenchymal stem cells (MSCs) can differentiate into many kinds of cells, \nincluding neuronal cells. In this study, we intranasally administrated the \nconditioned medium derived from cultured umbilical cord (UC) MSCs. The \nintranasal administration of the MSCs medium restored the cognitive impairment \nobserved in OBX mice. In addition, the decreased number of choline \nacetyltransferase-positive cells in the medial septum was restored by the \nconditioned medium administration. In conclusion, MSCs-derived conditioned \nmedium may have protective effects of cholinergic neurons in the medial septum, \nthereby rescuing the cognitive impairment of OBX.","PeriodicalId":57126,"journal":{"name":"阿尔茨海默氏病研究进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"阿尔茨海默氏病研究进展(英文)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4236/aad.2020.93004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Alzheimer’s disease (AD) is the common cause of
dementia which shows the neuro-pathologies like an accumulation of amyloid-β (Aβ)
and degeneration of cholinergic neuron. Olfactory bulbectomized (OBX) mice show
some of AD features, so they have been used to research as AD model.
Mesenchymal stem cells (MSCs) can differentiate into many kinds of cells,
including neuronal cells. In this study, we intranasally administrated the
conditioned medium derived from cultured umbilical cord (UC) MSCs. The
intranasal administration of the MSCs medium restored the cognitive impairment
observed in OBX mice. In addition, the decreased number of choline
acetyltransferase-positive cells in the medial septum was restored by the
conditioned medium administration. In conclusion, MSCs-derived conditioned
medium may have protective effects of cholinergic neurons in the medial septum,
thereby rescuing the cognitive impairment of OBX.