Evaluation of the antibacterial activity of zinc oxide nanoparticles doped with copper ions and co-doped with copper and silver ions

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Shadi Ashraf Nohegar, Arazoo Nejaei, E. Fataei, M. Ramezani, P. A. Eslami
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Abstract

The current feasibility study deals with the elimination of Escherichia coli (gram-negative) and Staphylococcus aureus (gram-positive) bacterial strains isolated from swimming pools using zinc oxide (ZnO) nanoparticles (NPs) doped with copper (Cu2+) ions (CuX%/ZnO NPs) and co-doped with copper (Cu2+) and silver (Ag+) ions (AgX%/CuY%/ZnO NPs) synthesized by sol-gel method. Antibacterial activity was evaluated by Agar well diffusion assay. As-produced NPs were characterized by X-ray diffraction, Field emission-scanning electron microscopy, Energy Dispersive X-Ray and Transmission electron microscopy techniques. The results showed that the size of the co-doped NPs was smaller than that of mono-doped NPs. Meanwhile, co-doped Ag5%/Cu5%/ZnO NPs had the maximum bactericidal activity, and the destructive effect on Gram-positive bacteria was greater than that on Gram-negative bacteria. The lowest effective nanoparticle concentrations were 0.1 and 0.05 g/mL. The main bactericidal mechanism, in addition to the size of co-doped NPs, was due to the formation of reactive oxygen species, so that the destruction of the bacterial cell wall and finally death occurred through the radicals formed.
铜离子掺杂和铜银离子共掺杂氧化锌纳米颗粒的抗菌活性评价
目前的可行性研究是利用溶胶-凝胶法合成的氧化锌纳米颗粒(NPs)掺杂铜(Cu2+)离子(CuX%/ZnO NPs)和共掺杂铜(Cu2+)和银(Ag+)离子(AgX%/CuY%/ZnO NPs)去除游泳池中分离的大肠杆菌(革兰氏阴性)和金黄色葡萄球菌(革兰氏阳性)菌株。用琼脂孔扩散法测定其抑菌活性。利用x射线衍射、场发射扫描电镜、能量色散x射线和透射电镜等技术对纳米粒子进行了表征。结果表明,共掺杂NPs的尺寸小于单掺杂NPs的尺寸。同时,共掺杂Ag5%/Cu5%/ZnO NPs的杀菌活性最大,且对革兰氏阳性菌的破坏作用大于对革兰氏阴性菌的破坏作用。最低有效纳米颗粒浓度分别为0.1和0.05 g/mL。除共掺杂NPs的大小外,主要的杀菌机制是由于活性氧的形成,从而通过形成的自由基破坏细菌细胞壁,最终导致死亡。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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