Evaluation of the antibacterial activity of zinc oxide nanoparticles doped with copper ions and co-doped with copper and silver ions

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Main Group Chemistry Pub Date : 2022-11-23 DOI:10.3233/mgc-220098

Shadi Ashraf Nohegar, Arazoo Nejaei, E. Fataei, M. Ramezani, P. A. Eslami

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引用次数: 0

Abstract

The current feasibility study deals with the elimination of Escherichia coli (gram-negative) and Staphylococcus aureus (gram-positive) bacterial strains isolated from swimming pools using zinc oxide (ZnO) nanoparticles (NPs) doped with copper (Cu2+) ions (CuX%/ZnO NPs) and co-doped with copper (Cu2+) and silver (Ag+) ions (AgX%/CuY%/ZnO NPs) synthesized by sol-gel method. Antibacterial activity was evaluated by Agar well diffusion assay. As-produced NPs were characterized by X-ray diffraction, Field emission-scanning electron microscopy, Energy Dispersive X-Ray and Transmission electron microscopy techniques. The results showed that the size of the co-doped NPs was smaller than that of mono-doped NPs. Meanwhile, co-doped Ag5%/Cu5%/ZnO NPs had the maximum bactericidal activity, and the destructive effect on Gram-positive bacteria was greater than that on Gram-negative bacteria. The lowest effective nanoparticle concentrations were 0.1 and 0.05 g/mL. The main bactericidal mechanism, in addition to the size of co-doped NPs, was due to the formation of reactive oxygen species, so that the destruction of the bacterial cell wall and finally death occurred through the radicals formed.

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铜离子掺杂和铜银离子共掺杂氧化锌纳米颗粒的抗菌活性评价

目前的可行性研究是利用溶胶-凝胶法合成的氧化锌纳米颗粒(NPs)掺杂铜(Cu2+)离子(CuX%/ZnO NPs)和共掺杂铜(Cu2+)和银(Ag+)离子(AgX%/CuY%/ZnO NPs)去除游泳池中分离的大肠杆菌(革兰氏阴性)和金黄色葡萄球菌(革兰氏阳性)菌株。用琼脂孔扩散法测定其抑菌活性。利用x射线衍射、场发射扫描电镜、能量色散x射线和透射电镜等技术对纳米粒子进行了表征。结果表明，共掺杂NPs的尺寸小于单掺杂NPs的尺寸。同时，共掺杂Ag5%/Cu5%/ZnO NPs的杀菌活性最大，且对革兰氏阳性菌的破坏作用大于对革兰氏阴性菌的破坏作用。最低有效纳米颗粒浓度分别为0.1和0.05 g/mL。除共掺杂NPs的大小外，主要的杀菌机制是由于活性氧的形成，从而通过形成的自由基破坏细菌细胞壁，最终导致死亡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Main Group Chemistry 化学-化学综合

CiteScore

2.00

自引率

26.70%

发文量

审稿时长

>12 weeks

期刊介绍： Main Group Chemistry is intended to be a primary resource for all chemistry, engineering, biological, and materials researchers in both academia and in industry with an interest in the elements from the groups 1, 2, 12–18, lanthanides and actinides. The journal is committed to maintaining a high standard for its publications. This will be ensured by a rigorous peer-review process with most articles being reviewed by at least one editorial board member. Additionally, all manuscripts will be proofread and corrected by a dedicated copy editor located at the University of Kentucky.