Catalytic performance of cadmium pyrophosphate in the knoevenagel condensation and one-pot multi-component reaction of chromene derivatives

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemical Sciences Pub Date : 2023-08-31 DOI:10.1007/s12039-023-02213-x

Soukaina Chehab, Youssef Merroun, Achraf Elhallaoui, Tourya Ghailane, Said Boukhris, Taoufiq Guedira, Rachida Ghailane, Abdelaziz Souizi

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引用次数: 1

Abstract

A simple, efficient, and eco-friendly process for the Knoevenagel condensation between various aromatic aldehydes and active methylene compounds and the synthesis of 2-amino-4H-chromene derivatives via a multi-component reaction of various aromatic aldehydes, malononitrile, and resorcinol catalyzed by mono-ammonium phosphate fertilizer (MAP) modified by cadmium chloride (CdCl₂) is described. This synthesis procedure is considered an attractive method due to its excellent yields, short reaction time, green conditions, cost-effectiveness, use of a non-toxic solvent, non-chromatographic purification of products, and recyclability of the catalyst.

Graphical abstract

A simple, efficient, and ecofriendly process is proposed to synthesize 2-amino-4H-chromene and 2-(4-chlorobenzylidene) malononitrile derivatives via the application of cadmium pyrophosphate (Cd₂P₂O₇) as catalyst prepared from the modification of mono-ammonium phosphate fertilizer (MAP) by adding cadmium chloride (CdCl₂). The products were obtained with good yields in a short reaction time.

Abstract Image

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焦磷酸镉在铬衍生物knoevenagel缩合及一锅多组分反应中的催化性能

本文介绍了一种简单、高效、环保的方法，通过多种芳香醛、丙二腈和间苯二酚的多组分反应，在氯化镉(CdCl2)修饰的磷酸一铵肥料(MAP)的催化下，进行各种芳香醛和活性亚甲基化合物之间的Knoevenagel缩合反应，合成2-氨基- 4h -铬衍生物。由于收率高、反应时间短、环境环保、成本效益高、使用无毒溶剂、产物无需色谱纯化、催化剂可回收等优点，该合成方法被认为是一种极具吸引力的合成方法。以焦磷酸镉(Cd2P2O7)为催化剂，用氯化镉(CdCl2)对磷酸一铵肥(MAP)进行改性，制备了一种简单、高效、环保的2-氨基- 4h -铬和2-(4-氯苄二烯)丙二腈衍生物。反应时间短，产率高。

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来源期刊

Journal of Chemical Sciences CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.10

自引率

5.90%

发文量

107

审稿时长

1 months

期刊介绍： Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.