Phase I/II Study to Investigate the Use of Gemcitabine in Combination with Raltitrexed in Locally Advanced or Metastatic Pancreatic Adenocarcinoma

Michael Agnieszka, M. Hill, A. Maraveyas, H. Wasan, F. Lofts
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引用次数: 1

Abstract

Adenocarcinoma of the pancreas remains one of the most difficult cancers to treat. Raltitrexed, a novel quinazoline analogue, combined with gemcitabine is likely to potentate the anti-cancer effect, as both of those drugs inhibit DNA synthesis via separate metabolic pathway. We report a phase I/II study of increasing dose of gemcitabine with raltitrexed in patients with advanced adenocarcinoma of the pancreas. The study was conducted at three different dose levels with raltitrexed at 3mg/m2 and increasing gemcitabine levels. 24 patients were recruited. Cohort 2 patient developed unexpected toxicity with 58% of patients experiencing haematological toxicity and 29% nausea and vomiting. The majority of patients complained of lethargy and 5 patients reached dose-limiting toxicity. Partial responses were documented in two out of 24 patients (8%), 25% had stable disease and 50% developed progressive disease. We found the combination of raltitrexed and gemcitabine active but poorly tolerated in pancreatic cancer.
吉西他滨联合雷替曲塞治疗局部晚期或转移性胰腺腺癌的I/II期研究
胰腺腺癌仍然是最难治疗的癌症之一。雷替曲塞是一种新型喹唑啉类似物,与吉西他滨联合可能会增强抗癌作用,因为这两种药物都通过不同的代谢途径抑制DNA合成。我们报告了一项I/II期研究,增加吉西他滨与雷替曲塞在晚期胰腺腺癌患者中的剂量。该研究在三种不同剂量水平下进行,雷曲塞为3mg/m2,吉西他滨逐渐增加。共招募了24名患者。队列2患者出现意想不到的毒性,58%的患者出现血液学毒性,29%的患者出现恶心和呕吐。多数患者表现为嗜睡,5例达到剂量限制性毒性。24例患者中有2例(8%)出现部分缓解,25%的患者病情稳定,50%的患者病情进展。我们发现雷替曲塞和吉西他滨联合治疗胰腺癌有效,但耐受性差。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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