Dithiocarbamate Modified SPION-Chitosan Nanobiocomposite, a Promising Adsorbent for Bovine Serum Albumin (BSA)

IF 3.5 Q2 CHEMISTRY, MULTIDISCIPLINARY
Esmail Doustkhah, M. Heydarizadeh, Z. Fathi, H. Mohtasham, S. Rostamnia, Morteza Hasani
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引用次数: 4

Abstract

In the present paper, bovine serum albumin (BSA) was studied for extraction case from a buffer solution through a new version of modified magnetic chitosan nanocomposite.  Post-modification of this magnetic chitosan led to conversion of amine groups to dithiocarbamate on the surface of chitosan which was wrapped to superparamagnetic iron oxide nanoparticles (SPION). Chitosan was converted to magnetic chitosan over co-precipitation of Fe2+ and Fe3+ under alkali conditions. Amines of chitosan were also converted to dithiocarbamate over the reaction of carbon disulfide. Study of the synthesized support in BSA extraction was achieved in further experiments.
二硫代氨基甲酸酯修饰spion -壳聚糖纳米生物复合材料对牛血清白蛋白的吸附剂研究
本文采用新型改性壳聚糖纳米复合材料,研究了从缓冲液中提取牛血清白蛋白(BSA)的情况。对该磁性壳聚糖进行改性后,壳聚糖表面的胺基转化为二硫代氨基甲酸酯,壳聚糖表面包裹有超顺磁性氧化铁纳米颗粒(SPION)。在碱性条件下,通过Fe2+和Fe3+共沉淀法将壳聚糖转化为磁性壳聚糖。壳聚糖中的胺类也通过二硫化碳反应转化为二硫代氨基甲酸酯。在进一步的实验中,对合成载体在牛血清白蛋白提取中的作用进行了研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Chemical Methodologies
Chemical Methodologies CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
3.10
自引率
1.80%
发文量
8
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