The diagnostic utility of endocytoscopy for the detection of gastric cancer: a systematic review and meta-analysis.

IF 0.4 3区历史学 Q1 HISTORY

European History Quarterly Pub Date : 2024-06-01 Epub Date: 2022-05-05 DOI:10.23736/S2724-5985.22.03172-2

Andrew Canakis, Shivanand Bomman, Benjamin Twery, Nevin Varghese, Byung Ji, Justin Canakis, Eric M Goldberg

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引用次数: 0

Abstract

Introduction: Endocytoscopy (ECS) is an evolving technology that utilizes ultra-high power magnification for real time cellular imaging without the need for physical biopsy. Its application for gastric cancer (GC) detection is not well evaluated at the current time, but there is potential that ECS can make a real time histopathological diagnosis to differentiate neoplastic from benign lesions. We aimed to investigate the diagnostic utility of ECS for GC detection.

Evidence acquisition: Literature searches through multiple databases were performed for studies using ECS for GC detection until November 2021. Measured outcomes included the pooled sensitivity, specificity and accuracy. Quality assessment of diagnostic studies tool was used to assess the risk of bias.

Evidence synthesis: Four studies (N.=245) were included. The pooled sensitivity was 83.5% (95% CI: 75-89%, I²: 0) and specificity was 91.7% (95% CI: 79-97%, I²: 58%). The pooled accuracy was 89.2% (95% CI: 83-94%, I²: 38%). There was a low risk of bias.

Conclusions: ECS is an accurate diagnostic modality and has the potential to serve as a complimentary tool in screening for GC. Larger prospective studies are needed to validate these findings before its further widespread use.

查看原文本刊更多论文

内镜在胃癌检测中的诊断作用：系统回顾和荟萃分析。

背景/目的：内细胞镜（ECS）是一种不断发展的技术，它利用超高倍放大技术进行实时细胞成像，而无需进行物理活检。目前，该技术在胃癌（GC）检测中的应用还没有得到很好的评估，但 ECS 有可能进行实时组织病理学诊断，以区分肿瘤和良性病变。我们的目的是研究 ECS 对胃癌检测的诊断效用：我们通过多个数据库检索了截至 2021 年 11 月使用 ECS 检测 GC 的研究文献。测量结果包括汇总灵敏度、特异性和准确性。诊断研究质量评估工具用于评估偏倚风险：结果：共纳入四项研究（n=245）。汇总灵敏度为 83.5%（95% CI：75% - 89%，I2：0），特异度为 91.7%（95% CI：79% - 97%，I2：58%）。汇总准确率为 89.2%（95% CI：83% - 94%，I2：38%）。偏倚风险较低：ECS是一种准确的诊断方式，有可能成为筛查GC的辅助工具。在进一步广泛使用之前，需要进行更大规模的前瞻性研究来验证这些结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European History Quarterly Multiple-

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： European History Quarterly has earned an international reputation as an essential resource on European history, publishing articles by eminent historians on a range of subjects from the later Middle Ages to post-1945. European History Quarterly also features review articles by leading authorities, offering a comprehensive survey of recent literature in a particular field, as well as an extensive book review section, enabling you to keep up to date with what"s being published in your field. The journal also features historiographical essays.