Influence of Carica Papaya Linn Extracts on Paracetamol and Thioacetamide Induced Hepatic Damage in Rats

Abstract

The Carica papaya Linn (Family Caricaceae) has been used for summer heat syndrome as home remedy in Japan and China, and it has recently been used to treat Paracetamol and Thioacetamide Induced Hepatic Damage in Rats in India. So we investigate the pharmacological effect of Carica papaya extracts (CPE).We examined the effect of CPE on rat models of paracetamol (PCM) and thioacetamide (TAA) induced hepatic damage. Wistar strain albino rats were prophylactically treated with three dose of CPE (100, 250 and 500mg/kg, p.o) for 10 days and subsequently liver damage was induced. Hepatoprotective potential was evaluated by measuring biomarkers and this is mainly due to the presence of vitamin C.