{"title":"Statistical Interaction In The Survival Analysis Of Early Breast Cancer Using Registry Data","authors":"Anne-Marie Danzel","doi":"10.5580/531","DOIUrl":null,"url":null,"abstract":"Purpose: An interaction analysis is used to investigate subgroup effects between breast conserving surgery, radiotherapy and nodal status in early breast cancer. Patients and methods: Women selected from the SEER database, aged 40-69 with non metastasized T1-T2 breast cancer and in whom axillary node dissection was performed. The method uses proportional hazards regression models with interaction terms. Steps of the analysis are detailed. Results: Significant statistical interactions were found between breast conserving surgery, radiotherapy , nodal involvement and T stage. In an integrated factorial presentation of results, patients undergoing breast conserving surgery without radiotherapy were not at survival disadvantage as compared with patients undergoing mastectomy, irrespective of T-stage and irrespective of nodal involvement. However, the addition of radiotherapy to breast conserving surgery was associated with a distinct survival advantage observed in all T stage and all levels of nodal involvement. Conclusion: The analysis of interactions provides a comprehensive view of complex subgroup effects. The formal presentation of results might be useful as a framework to generate hypotheses for further investigations.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2004-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Internet Journal of Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5580/531","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Purpose: An interaction analysis is used to investigate subgroup effects between breast conserving surgery, radiotherapy and nodal status in early breast cancer. Patients and methods: Women selected from the SEER database, aged 40-69 with non metastasized T1-T2 breast cancer and in whom axillary node dissection was performed. The method uses proportional hazards regression models with interaction terms. Steps of the analysis are detailed. Results: Significant statistical interactions were found between breast conserving surgery, radiotherapy , nodal involvement and T stage. In an integrated factorial presentation of results, patients undergoing breast conserving surgery without radiotherapy were not at survival disadvantage as compared with patients undergoing mastectomy, irrespective of T-stage and irrespective of nodal involvement. However, the addition of radiotherapy to breast conserving surgery was associated with a distinct survival advantage observed in all T stage and all levels of nodal involvement. Conclusion: The analysis of interactions provides a comprehensive view of complex subgroup effects. The formal presentation of results might be useful as a framework to generate hypotheses for further investigations.