To Medical Oncologists: Can We Safely Trust and Recommend the Robot Assisted Radical Prostatectomy?

G. Hachem
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引用次数: 0

Abstract

Widespread screening using serum prostate specific antigen (PSA) and digital rectal exam (DRE) resulted in an increased incidence of early diagnosis of prostate cancer. The surgery remains the mainstay treatment of early localized prostate adenocarcinoma, especially in young population. Radical prostatectomy can be performed via an open surgery requiring a large vertical incision or via a minimally invasive technique consisting of laparoscopic radical prostatectomy (LRP) or robot assisted radical prostatectomy (RARP). The main risks and complications of any radical surgical procedure are the bleeding and infectious risks, the post-operative recovery (pain, hospital stay) and most importantly the oncologic outcomes (to have negative margins and complete radical excision of the tumor, to avoid recurrence, to improve survival). Besides, radical prostatectomy has other specific complications related to the anatomic localization of the prostate gland: erectile dysfunction, urinary incontinence, urethral strictures and impotence. Thus, the least debilitating surgical procedure associated with an excellent oncologic control without affecting the quality of life remained a challenge for many years especially that the results of the minimally invasive LRP weren’t so promising at the beginning.
致肿瘤内科医生:我们能安全地信任和推荐机器人辅助根治性前列腺切除术吗?
广泛使用血清前列腺特异性抗原(PSA)和直肠指检(DRE)筛查导致前列腺癌早期诊断的发生率增加。手术仍然是早期局限性前列腺癌的主要治疗方法,特别是在年轻人中。根治性前列腺切除术可以通过需要大垂直切口的开放手术进行,也可以通过微创技术进行,包括腹腔镜根治性前列腺切除术(LRP)或机器人辅助根治性前列腺切除术(RARP)。任何根治性手术的主要风险和并发症是出血和感染风险、术后恢复(疼痛、住院),最重要的是肿瘤预后(阴性切缘和完全根治性切除肿瘤,避免复发,提高生存率)。此外,根治性前列腺切除术还存在其他与前列腺解剖定位相关的特殊并发症:勃起功能障碍、尿失禁、尿道狭窄和阳痿。因此,多年来,在不影响生活质量的情况下,在良好的肿瘤控制下,最小的衰弱外科手术仍然是一个挑战,特别是微创LRP的结果在开始时并不那么有希望。
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