The Emerging Role of microRNAs as Novel Diagnostic and Therapeutic Tools For Breast Cancer: a systematic review

Journal of Biology and Life Science Pub Date : 2023-04-14 DOI:10.37185/lns.1.1.268

S. Mumtaz, R. Saeed, A. Qazi, N. Akhtar, U. Awan

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Abstract

Objective: A systematic review was conducted to evaluate recent studies performed on miRNAs as a diagnostic and therapeutic biomarker in breast cancer.Study Design: Online standard databases like PubMed, EMBASE, Web of Science and COCHRANE library were searched to identify research articles relavant to the topic. Place and Duration of Study: All online published studies between 2010-2020, in the scientific electronic databases were analyzed.Materials and Methods: This review was performed according to PRISMA guidelines. Databases were systematically analyzed to explore the diagnostic and therapeutic potentials of miRNAs in breast cancer.Results: We identified twenty-seven studies after literature search. We found six studies focused on diagnosis, sixteen on therapeutics and five on both diagnosis and therapeutics of miRNAs in breast cancer.Conclusion: The combined data obtained in the present systematic review specify that miRNAs could serve as novel diagnostic and therapeutic biomarkers in breast cancer, whereas the practical relevance of the current results has yet to be established.

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microRNAs作为新型乳腺癌诊断和治疗工具的新作用:系统综述

目的:对mirna作为乳腺癌诊断和治疗生物标志物的最新研究进行了系统回顾。研究设计:检索PubMed、EMBASE、Web of Science和COCHRANE等在线标准数据库，以确定与主题相关的研究文章。研究地点和时间:在科学电子数据库中分析了2010-2020年间所有在线发表的研究。材料和方法:本综述按照PRISMA指南进行。系统分析数据库，探讨mirna在乳腺癌中的诊断和治疗潜力。结果:通过文献检索，我们确定了27项研究。我们发现6项研究集中在乳腺癌的诊断上，16项研究集中在治疗上，5项研究集中在mirna的诊断和治疗上。结论:本系统综述中获得的综合数据表明，miRNAs可以作为乳腺癌的新型诊断和治疗生物标志物，但目前结果的实际相关性尚未确定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Biology and Life Science

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