Disintegration Properties and Drug Release Profiles of Sodium Alginate Films Containing Rebamipide

Abstract

Sodium alginate [Alg-Na], an algal polysaccharide consisting of α-L-guluronate and β-Dmannuronate, is used as a food ingredient [1]. Some species of Alg-Na have been widely utilized as excipients in drug products and/or as impression materials in dentistry due to their polymeric properties and safe oral intake [2-4]. Alg-Na itself enacts a protective effect on the gastric mucosa; thus, it has been used as a medicine for the treatment of gastroesophageal reflux disease [5,6].