Considerations on the mechanisms involved on the benefits of GM1 treatment of mice with experimental Chagas´ disease

Abstract

Methods: 160 three months old outbreed Albino Swiss mice were divided into four groups: a) non-infected, b) non-infected and treated with GM1 0,1 mg /day by intramuscular injection, for 30 days, c) infected with T. cruzi, 0.710 parasites, d) infected with T. cruzi, 0.710 parasites and treated with GM1 0,1 mg /day by intramuscular injection for 30 days. The animals were studied at 35 days from the beginning of treatment and at 120 days post treatment. Cardiomyocyte membranes were isolated and β adrenergic receptors, membrane fluidity and composition, plasma glucose, potassium, DHA, estradiol and cortisol were determined. Histological sections of heart and adrenal glands were examined.