Effects of Gibberellic Acid on Thioacetamide-Induced Acute Liver Toxicity in Sprague-Dawley Rats

The Pakistan Veterinary Journal Pub Date : 2022-10-01 DOI:10.29261/pakvetj/2022.025

Haytham Mohamedelfatih Mohamed Makki

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引用次数: 4

Abstract

Gibberellic acid (GBA) is a natural plant growth hormone, controlling many developmental processes. In order to explore the protective effects of GBA against Thioacetamide (TAA)-induced acute liver toxicity, thirty male Sprague-Dawley (SD) rats were randomly allocated into six groups (5 rats/group); Normal control (NC): received distilled water (DW) per os (p.o.), GBA only: received (20 mg/kg, p.o.) of GBA, TAA: received DW and TAA (350 mg/kg, i.p.), GBA 5: received GBA (5 mg/kg, p.o.) and TAA (350 mg/kg, i.p.), GBA 10: received GBA (10 mg/kg, p.o.) and TAA (350 mg/kg, i.p.), and GBA 20: received GBA (20 mg/kg, p.o.) and TAA (350 mg/kg, i.p.). Blood and plasma were collected for biochemical analysis while liver tissues were harvested and preserved for histological analysis. The results confirmed the TAA-induced acute liver toxicity by the significantly increased liver enzymes, hypoglycemia, hypoxia, polycythemia, and metabolic acidosis as compared with NC. However, pretreatment of TAA-intoxicated rats with GBA indicated the hepatoprotective effects by reducing liver enzyme levels significantly and alleviating hepatic lesions in a dose-dependent manner

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赤霉素酸对硫代乙酰胺致sd大鼠急性肝毒性的影响

赤霉素(Gibberellic acid, GBA)是一种天然的植物生长激素，控制着许多植物发育过程。为探讨GBA对硫代乙酰胺(TAA)致急性肝毒性的保护作用，将30只雄性SD大鼠随机分为6组(5只/组);正常对照组(NC):每os (p.o)接收蒸馏水(DW)，仅GBA:接收GBA (20 mg/kg, p.o)， TAA:接收DW和TAA (350 mg/kg, i.p)， GBA 5:接收GBA (5 mg/kg, p.o)和TAA (350 mg/kg, i.p)， GBA 10:接收GBA (10 mg/kg, p.o)和TAA (350 mg/kg, i.p)， GBA 20:接收GBA (20 mg/kg, p.o)和TAA (350 mg/kg, i.p)。采集血液和血浆进行生化分析，采集肝组织保存用于组织学分析。与NC相比，taa引起的肝酶、低血糖、缺氧、红细胞增多症和代谢性酸中毒明显增加，证实了taa引起的急性肝毒性。然而，taa中毒大鼠GBA预处理显示其肝保护作用，显著降低肝酶水平，并以剂量依赖的方式减轻肝脏病变

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Pakistan Veterinary Journal

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