Synthesis of niosomes of diclofenac sodium and their microscopic evaluation

Muhammad Zaid, Khalil Ahmed, Awais Rasool, Muhammad Adeel
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引用次数: 1

Abstract

Objective: Incorporation of drugs into non-ionic surfactant vesicles (niosomes) during their manufacture affords apossible method of achieving controlled release. The aim of this study was to formulate niosomes as carriers for delivery of diclofenac sodium (DCS) to achieve controlled release. Method: Niosomes were prepared by Ether injection method using non-ionic surfactant (Span 80) and cholesterol in ratio of 1:1, the organic solvent (dichloromethane) and phosphate buffer. Results: The prepared niosomes were then evaluated for physical appearance, light microscopy, optical microscopy, transmission electron microscopy and entrapment efficiency.Conclusion: Diclofenac sodium niosomes were prepared successfully without using charge inducing surfaces andwere confirmed by microscopic evaluation. 
双氯芬酸钠小体的合成及其显微评价
目的:在药物生产过程中将药物掺入非离子表面活性剂囊泡(小体)中,为实现药物控释提供了可能的方法。本研究的目的是制备膜小体作为双氯芬酸钠(DCS)控释的载体。方法:以非离子表面活性剂(Span 80)与胆固醇按1:1的比例,有机溶剂(二氯甲烷)和磷酸盐缓冲液为原料,采用乙醚注射法制备乳小体。结果:对制备的纳米体进行了物理外观、光镜、光学显微镜、透射电镜和包封效率的评价。结论:双氯芬酸钠纳米体制备成功,无需使用电荷诱导表面,并经显微评价证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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