SUB-ACUTE DERMAL TOXICITY OF SODIUM-CONTAINING DRUGS

Abstract

Drugs that have antimicrobial, anti-inflammatory and wound-healing effects deserve special attention, sodium-containing drugs are one of them, which is why they are used in veterinary medicine. The article presents the results of experimental studies to study the sub-acute toxicity of sodium-containing drugs: known – glycetinate 2%, its analogues – ovocid 2%, ovocid 3%, potassium-sodium 1.5% (Na / K, 1.5%). The study of sub-acute toxicity of drugs was carried out by applying drugs to the skin of animals. The experiment used white rats weighing 250-270 g. 4 groups of rats with 3 animals in each were formed: rats of group I on the skin was applied ovocid 3%, group 2 - Na / K drug 1.5%, 3rd group – ovocide 2%, and the 4th group of rats (control) was applied glycetinate 2%. The animals were subjected to clinical observations, assessing their general condition and skin reaction. The effect of drugs on morphological and biochemical parameters of blood of rats was studied. Evaluating the general condition, behavior, local skin reaction of rats for the study of subacute toxicity, local irritant action of sodium-containing drugs, it was noted that they did not cause visible violations of physiological functions, the appearance of clinical signs of intoxication. No significant clinical signs of inflammation or irritation (erythema, edema, and cracks) were recorded on the skin of the animals. At the same time, it should be noted that the animals of all experimental groups had a slight redness at the place of application of the drugs, which later disappeared.