Human transient receptor potential (TRP) channel expression profiling in carcinogenesis.

M. Bernardini, A. Fiorio Pla, N. Prevarskaya, D. Gkika
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引用次数: 25

Abstract

Despite the intensive research of the last three decades into Transient Receptor Potential (TRP) cation channels, no precise and complete profiling of these channels is yet available regarding their involvement in physiopathology and carcinogenesis in particular. TRP channel activity is crucial for all the essential hallmarks of carcinogenesis such as proliferation, apoptosis, migration and angiogenesis, which is the reason why these channels have been proposed not only as clinical markers, but also as promising targets for anti-cancer therapy. However, in the majority of studies, each channel has been considered as a separate molecular entity and studied independently from the other TRPs, while a complete "transportome" of the specific stages of carcinogenesis is required for the effective use of these targets. This review focuses on the partial TRP expression profiles found in the literature and the means by which a full TRP signature could be achieved.
人瞬时受体电位(TRP)通道在癌变中的表达谱。
尽管过去三十年来对瞬时受体电位(TRP)阳离子通道进行了深入的研究,但这些通道在生理病理和癌症发生中的作用尚未得到精确和完整的描述。TRP通道活性对于肿瘤发生的所有基本特征(如增殖、凋亡、迁移和血管生成)至关重要,这就是为什么这些通道不仅被提出作为临床标志物,而且作为抗癌治疗的有希望的靶点。然而,在大多数研究中,每个通道都被认为是一个单独的分子实体,独立于其他trp进行研究,而有效利用这些靶点需要一个完整的致癌特定阶段的“运输组”。这篇综述的重点是在文献中发现的部分TRP表达谱和实现完整TRP签名的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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