Φαρμακογονιδιωματική: Ηθικά διλήμματα

IF 0.4 4区 哲学
Θωμάς Κορδόνης
{"title":"Φαρμακογονιδιωματική: Ηθικά διλήμματα","authors":"Θωμάς Κορδόνης","doi":"10.12681/BIOETH.19691","DOIUrl":null,"url":null,"abstract":"In the present article I will depict some of the emerging controversies that are expected to be of serious concern in the developing field of pharmacogenomics. Pharmacogenomics is the branch of genetics concerned with determining the likely response of an individual to therapeutic medications. The first upcoming issue is the voluntary agreement of the patients, concerning the research of their genome, that is also reflected in their relatives, as well as in their wider social group (s). Secondly, the great financial costs of pharmacogeonomic therapies is most likely to lead to new social inequalities or upsurge the existing ones in commodity of health. Furthermore, this will possibly lead to more group minorities, based on the rarity of some alleles among individuals and their following response to the applied medication. As for cognitive functions, pharmacogenomics seems to be a great challenge for the enhancement of both cognitive dysregulation in patients and intellectual ability in healthy individuals. Consequently, this will lead to an unbridgeable gap between the users and nonusers of newer medications regarding their intellectual abilities, that are unachievable by normal training of physical abilities. Last but not least, l will refer to whether or not genetic data regard strictly confidential personal data, not allowed to be published, despite of possible social benefit and to what extent their carrier has the right of ignoring it.","PeriodicalId":49112,"journal":{"name":"Acta Bioethica","volume":"1 1","pages":""},"PeriodicalIF":0.4000,"publicationDate":"2018-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Bioethica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12681/BIOETH.19691","RegionNum":4,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

In the present article I will depict some of the emerging controversies that are expected to be of serious concern in the developing field of pharmacogenomics. Pharmacogenomics is the branch of genetics concerned with determining the likely response of an individual to therapeutic medications. The first upcoming issue is the voluntary agreement of the patients, concerning the research of their genome, that is also reflected in their relatives, as well as in their wider social group (s). Secondly, the great financial costs of pharmacogeonomic therapies is most likely to lead to new social inequalities or upsurge the existing ones in commodity of health. Furthermore, this will possibly lead to more group minorities, based on the rarity of some alleles among individuals and their following response to the applied medication. As for cognitive functions, pharmacogenomics seems to be a great challenge for the enhancement of both cognitive dysregulation in patients and intellectual ability in healthy individuals. Consequently, this will lead to an unbridgeable gap between the users and nonusers of newer medications regarding their intellectual abilities, that are unachievable by normal training of physical abilities. Last but not least, l will refer to whether or not genetic data regard strictly confidential personal data, not allowed to be published, despite of possible social benefit and to what extent their carrier has the right of ignoring it.
在本文中,我将描述一些正在出现的争议,这些争议预计将在药物基因组学的发展领域引起严重关注。药物基因组学是遗传学的一个分支,研究个体对治疗性药物的可能反应。即将面临的第一个问题是患者自愿同意对其基因组进行研究,这也反映在他们的亲属以及更广泛的社会群体中。其次,药物基因组疗法的巨大财务成本最有可能导致新的社会不平等或加剧现有的健康商品不平等。此外,基于个体中某些等位基因的稀缺性以及他们对应用药物的后续反应,这可能会导致更多的少数群体。在认知功能方面,药物基因组学似乎是一个巨大的挑战,既可以改善患者的认知失调,也可以改善健康个体的智力。因此,这将导致使用者和非使用者之间在智力能力方面存在不可逾越的差距,这是通过正常的身体能力训练无法达到的。最后但并非最不重要的是,我将提及基因数据是否被视为严格保密的个人数据,不允许公布,尽管可能带来社会效益,以及它们的载体在多大程度上有权忽略它。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Acta Bioethica
Acta Bioethica 医学-卫生政策
CiteScore
0.60
自引率
0.00%
发文量
22
审稿时长
1 months
期刊介绍: Acta Bioethica is a biannual publication by the Interdisciplinary Center for Studies in Bioethics of the University of Chile (ISSN 0717-5906, press edition, y 1726-569-X, electronic edition), which publishes in three languages: Spanish, English and Portuguese. Indexed in Science Citation Index (SCI), Scopus, Lilacs, SciELO y Latindex, and in database from several Institutions; it constitutes a pluralistic source of perspectives and an important tribune which accepts the contributions of authors compromised with the interdisciplinary study of ethical determinants and consequences of techno scientific research.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信